The Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are a group of autoantibodies directed against cytoplasmic components of the neutrophilic granulocytes. They have been classified into cytoplasmic (c-ANCA) and perinuclear (p-ANCA) according to the indirect immunofluorescence pattern they give on ethanol-fixed human neutrophils and are useful serological markers for vasculitides.
Most p-ANCA antibodies (90%) recognize MPO antigen and have been reported in a variety of vasculitides (e.g. Microscopic Polyangiitis, Churg-Strauss Syndrome, Polyarteritis Nodosa) and Glomerulonephritides (e.g. Rapidly Progressive Glomerulonephritis).
Purified from human neutrophils (for more information on our antigens click here)