SRP antibodies are highly specific for Polymyositis. About 5 % of Myositis patients are positive for anti-SRP antibodies, rising to 18 % in the subgroup of Jo-1 negative patients.

In contrast to Myositis patients with aminoacyl-tRNA synthetase antibodies, SRP positive patients do not show involvement of the joints, lungs or skin. The classic « anti-SRP syndrome » is a severe form of Polymyositis with acute Myositic inflammation and frequent cardiac involvement. Patients generally respond poorly to immunosuppressive therapy. They have the poorest prognosis of all patients with Myositis.


Antigen used by D-tek

Recombinant, human, expressed in Baculovirus-infected Sf9 cells (for more information on our antigens click here)