Nucleosome consists of a sequence of DNA wrapped around a Histone octamer. They are responsible of the compactness of DNA in the nucleus.
Nucleosome antibodies are important markers for Systemic Lupus Erythematosus (SLE). These autoantibodies have an important predictive value as they appear at an earlier stage than anti-dsDNA antibodies.
They are also a significant marker of Lupus Nephritis, anti-Nucleosome complexes forming deposits on the Glomerular Basement Membrane. As such, anti-Nucleosome antibodies appear to be more specific markers of Lupus Nephritis than anti-dsDNA antibodies, explaining the discrepancies for cases in which anti-dsDNA antibodies do not correlate with a renal involvement.
Purified from bovine thymus chromatin (for more information on our antigens click here)