Centromere antibodies, also called Anti-Centromere Antibodies (ACA), are directed against Centromere-associated Proteins (CENP) and mainly two polypeptides designated CENP-A (19 kD) and CENP-B (80 kD).

Antibodies against CENP-A are most of the time detected in combination with antibodies against CENP-B. However, it is reported that CENP-A antibodies can be found in Scleroderma patients before the expression of CENP-B antibodies.

The combined detection of CENP-A and CENP-B antibodies is highly specific for systemic sclerosis (diagnostic specificity up to 99 %). With the determination of CENP-A and CENP-B antibodies nearly all of the systemic sclerosis relevant anti-centromere antibody reactivities as seen by indirect immunofluorescence on HEp-2 cells can be detected.


Antigen used by D-tek

Recombinant, human, expressed in Baculovirus infected Sf9 cells (for more information on our antigens click here)